Associate Director, Pharmacology & DMPK Job

Job Description
Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider the Celgene family.

PhD in Pharmacology or Pharmaceutical Sciences with 6-10 years experience in Discovery Research functions in the pharmaceutical industry

Position Summary:

The Associate Director of Pharmacology & DMPK will assume primary responsibility for leadership of a small group of pharmacology and metabolism scientists and research associates, providing pharmacology and DMPK support for the discovery teams. Broad subject expertise should include:

1. Experience in establishing and maintaining disease models in animals and in extracting interpretable data from experiments designed to assess the effects of drug candidates.

2. Experience in screening novel small molecules for exposure in standard PK models in mice and rats.

3. A working knowledge of bioanalytical methods and concepts that enables measurement of plasma levels of parent compounds and potential metabolites in plasma samples obtained from the experiments outlined above in (1) and (2).

4. A working knowledge of the wide range of in vitro ADME assays employed to assess the pharmaceutical properties and potential toxicology or clearance mechanisms of novel compounds (e.g., Caco-2 permeability, microsome stability, S9 fraction stability, CypP450 assays, hERG inhibition, SGF stability, plasma or serum or whole blood stability, etc.).

5. Experience in developing and implementing novel pharmacodynamic endpoint analyses.

6. Experience in building and maintaining an internal animal facility that is run in an efficiently and in compliance with all relevant regulations.

7. Established and evident fluency in explaining experimental designs, technical constraints, and interpretation of data to diverse and energized project teams.

8. Experience organizing and presenting data packages that support the transition of development candidates into early development.

The successful candidate will have excellent communication skills and be required to interface with the biology and chemistry leads on discovery program teams and provide guidance and technical expertise in support of early pharmacokinetic evaluation of small molecules and also to guide and implement in-house PK-PD efforts. The ability to evaluate and implement appropriate pharmacology models and to design and oversee a wide range of pharmacology experiments is required. The role requires oversight of Celgene’s in-house pharmacology capabilities in Bedford and, more broadly, through monitoring and oversight of externally contracted pharmacology studies. Vendor selection and monitoring for quality assurance will be the responsibility of this individual. Also required will be (1) the ability to provide in-house PK study design and implementation, (2) oversight of sample analysis and development of novel analytical methods as needed, (3) modeling and evaluation of data, and (4) management the laboratory animal facility with attention to both efficiency and compliance.

Exceptional organizational skills will be required to meet the demands of multiple internal customers with the allocated resources. It will be expected that the AD will contribute significantly to the development and implementation of the discovery strategy for the Bedford research unit as well as contribute to the advancement of the drug discovery programs. It is important that the successful candidate be able to communicate pharmacology and early discovery ADME (in vitro and in vivo) concepts and methods to the discovery teams as well as provide insight and perspective on the data provided.

Responsibilities include, but are not limited to, the following:


1. Directs Celgene Avilomics Research Pharmacology, both internally and externally: The Associate Director will be responsible for leading the overall scientific, technical, and operational efforts of the Pharmacology and DMPK groups in support of Discovery Project Teams. This will include selecting appropriate models for the therapeutic areas and ensuring the quality and interpretation of the data produced from the experiments, both internally or externally.

2. Scientific Excellence in Discovery: Will set the standard for high-quality research within the Pharmacology and DMPK group at CAR. Contributes to regular review of the project strategy and progress towards the nomination of a Development Candidate.

3. Collaboration Opportunities: Will be responsible for identifying potential collaborations in academia or industry to enhance the function of Pharmacology and the appropriateness of the models employed in support of the Project Teams.

4. Manages Internal Project Support: Will be responsible for the quality, quantity, and timeliness of Pharmacology and DMPK experiments for Project Teams. Will facilitate transition from Discovery to Non-clinical and coordinate execution of plans with key stakeholders. Will allocate resources and ensure tracking and follow-up as necessary.

5. Department Management: Will be responsible for setting high standards and building and managing a high-performance group. Will identify group needs and recruit, hire, promote personnel as appropriate. Will develop internal talent through coaching, training, and other experiences that meet the needs of the individual and the organization. Will allocate proper resources for meeting goals and objectives. Responsible for budget, including external collaboration expenses, capital and personnel requirements.

6. Communications: Will maintain productive communications with colleagues in biology, chemistry, Development, and the broader Celgene community. Will establish effective partnerships through inter-disciplinary collaborations, build expertise in current and future analytical technologies, and enable seamless transfer of information across teams.

7. Leadership: Sets high performance expectations and holds others accountable for results.

- Encourages and introduces new ideas, processes, and approaches.

- Promotes a culture of scientific and technical excellence, multidisciplinary problem solving, teamwork, flexibility, execution against goals, and effective communication.

- Anticipates needs, assesses and manages business risks, and organizational dynamics as well as their implications.


Skills/Knowledge Required:

- PhD in Pharmacology or Pharmaceutical Sciences.

- 6-10 years experience in Discovery Research functions in the pharmaceutical industry

- Scientific knowledge and experience in drug discovery, DMPK, and ADME. Specific interests and knowledge in oncology, immunology, and inflammation diseases a plus. Maintains current awareness in areas of expertise.

- Excellent leadership, managerial, and problem-solving skills

Excellent written and communication skills to effectively represent vision, mission and accomplishments of the Pharmacology /DMPK group.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Celgene support of a potential employee’s temporary visa application be construed to guarantee success of that application or amend or otherwise invalidate the ""at-will"" employment relationship between the employee and Celgene.

Company

Celgene

Job Code

State or Province

Massachusetts

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