Scientist, Drug Product Process Development

Job Description
Development of Gene Therapy Products
Tracking Code 79-807 Job Description

bluebird bio is developing potentially transformative, one-time gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio’s product creation efforts is its broadly applicable gene therapy platform for the development of new treatments for diseases with few or no clinical options. bluebird bio has two clinical stage product candidates in development, one for childhood cerebral adrenoleukodystrophy (CCALD) and one for beta-thalassemia major/sickle cell disease, and an early stage oncology program in partnership with Celgene Corporation.



Join bluebird bio’s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. The focus of this position is to provide support for the development, qualification and characterization of the CAR-T manufacturing process including the establishment of critical process parameters and controls for manufacturing. We are looking for an innovative scientist with the breadth of experience and drive to implement our vision for this function.



About the position:
•Under guidance of your supervisor, responsible for defining and driving the scientific strategy for pre-clinical scale-up of adoptive cellular therapy manufacturing processes for the treatment of a variety hematological and solid tumor cancers
•Responsible for managing and troubleshooting the daily activities of two associate scientists working in the lab
•Responsible for writing/reviewing experimental plans and managing experimental timelines to meet corporate goals
•Act as a technical liaison between the research immunology group and development group
•Point person for reviewing, and summarizing data via technical reports, batch records, etc.
•Responsible for researching and developing new strategies for isolating and culturing of primary cells for therapeutic purposes
•Must be willing to have a flexible schedule based on experimental and company needs (including possible weekend work and travel)



About you:
•MS with 5-10 years of experience or a PhD with 3-6 years of experience in cell therapy, gene therapy, or related field
•Previous experience managing others in a laboratory setting
•Have in-depth understanding and experience with large scale, closed system manufacturing of therapeutic cell and/or gene therapy products from whole blood, apheresis, or bone marrow
•Willingness to work with lentiviral vector and human biological samples including large volumes of blood
•Superb aseptic technique and experience working in a cGMP environment
•Proficient in a variety of biological assays such as ELISA, QPCR, Cytotoxicity, Proliferation and Flow Cytometry
•Familiar with common cellular therapy equipment (e.g. Haemonetics Cell Saver 5, Elutra Cell Separator and CliniMACS device)
•Excellent organization skills, sufficient to multi-task in an extremely fast-paced environment with constant changing priorities.
•Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view
•Independently motivated, detail oriented and good problem solving ability
•Excellent communication skills and ability to influence across multiple functions
•Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself

Company

bluebird bio

Job Code

State or Province

Massachusetts

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