Scientist, Prokaryotic/ Eukaryotic Genome Engineering

Job Description
The Scientist, Prokaryotic Eukaryotic Genome Engineering will work closely with a team of Molecular Engineering scientists in a biotechnology company developing innovative gene-based tools and engineered proteins for clinical and industrial applications.


Job Snapshot:
Posted On:9/17/2012 6:51:52 AM
Location:Germantown, MD
Department:Research
Job Type:Full Time
Education:Doctorate
Experience:1 - 5 Years
Reference Id:154
Travel Required:None
Manage Others:No


Description:
POSITION SUMMARY

The qualified candidate will work closely with a team of Molecular Engineering scientists in a
biotechnology company developing innovative gene-based tools and engineered proteins for clinical and
industrial applications.

Lead laboratory projects to develop efficient methods for site-specific integration of complex transgenes in organisms from bacteria to humans using cutting-edge genome engineering technologies.

Develop optimized protein expression strains through knockout, knockin, and mutagenesis of relevant pathways.

Characterize the activity of novel recombinases and integrases and identify the genomic targets of these enzymes experimentally.

Alter the substrate specificities or biological activities of target proteins through mutagenesis, gene shuffling, and/or protein engineering approaches.

Experimentally evaluate gene delivery reagents/ devices for utility across prokaryotic and eukaryotic platforms and develop optimized protocols.

EDUCATION
Ph.D. or Masters of Science in Biological Sciences (Molecular Biology, Genetics, Cell Biology,
Synthetic Biology, or related field)

EXPERIENCE

0-1 years post PhD experience or 5+ years post Masters of Science

3+ years hands-on experience in genome engineering of a prokaryotic or eukaryotic organism.

5+ years hands-on molecular biology experience, including genomic cloning expertise.

Experience with gene shuffling, integration-site cloning, and site-directed mutagenesis is preferred, but not required.

Experience developing and performing statistically validated quantitative biological assays is preferred but not required.

Proficiency in analyzing genomic sequence data through bioinformatics approaches is required.

Proficiency in common bioinformatics programming languages, such as Perl, Python, or Java is a plus.

Other Minimal Qualifications

Ability to achieve in a milestone-driven, rapidly changing research environment.

Good verbal and written communication skills and interpersonal skills.

Good planning, organization, and execution skills.

Possess a high degree of personal responsibility.

Ability to work collaboratively in a team environment with scientists of different backgrounds and experience levels.

Demonstrates the highest ethical standards and trustworthiness.

Ability to handle the dynamic, fast-paced, and multi-tasking environment of a rapidly growing biotech company.

Company

Intrexon Corp

Job Code

State or Province

Maryland

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