Senior Scientist / Staff Scientist (Ph.D. level)

Job Description
Reports to: Director, Analytical Development and Quality Control

Summary:
Selecta Biosciences is looking for a Ph.D. level Sr. Scientist / Staff Scientist to join its Analytical Development group. The successful candidate will have demonstrated analytical development experience dealing with various types of molecules, including biomolecules, and a variety of physicochemical techniques. The position will be an individual contributor that will help design and apply analytical methods to the company's proprietary Synthetic Vaccine Particle platform.

Primary Duties and Responsibilities:
The primary responsibility will be to develop separation methods for content and purity of various molecules. A wide breadth of analytical techniques will be used including but not limited to HPLC (RP, SEC and GPC), with UV/Vis, fluorescence, ELSD, or Refractive Index detection, electrophoresis and hyphenated mass spectrometry. The developed methods will target a wide variety of molecules including small molecules, peptides, proteins, oligosaccharides, oligonucleotides, and synthetic polymeric materials.

The Senior Scientist / Staff Scientist will have a demonstrated track record in method development with a variety of molecules and additional strengths in orthogonal analytical techniques using NMR, moisture analysis, residual solvent analysis, light scattering, and complementary HPLC methods to confirm primary results.

The analytical development group interacts closely with the chemistry, formulation development, process development, and bio-analytical groups. The successful candidate will provide oversight for routine HPLC analysis, data review and trending, and method development within and across groups. The individual will also work at times in a GMP compliant environment to support production, regulatory filings and stability programs.

This individual will demonstrate the ability to work independently, mentor other Scientists and Research Associates as well as be a strong individual contributor and work well in a team environment.

Educational and Experience Requirements

A PhD in chemistry or related field is required with a minimum of 5 years of experience in pharmaceutical analytical development. Title and compensation will be commensurate to experience.

Additional requirements include:

Expertise in HPLC separations including normal-phase, reversed-phase, and GPC with a variety of detection modes and instrument maintenance

Analytical experience in handling small sample quantities, sample preparation and extraction methods

Critical-thinking in method design and data analysis

Familiarity with data chromatographic systems such as Agilent Chemstation (ability to design methods and establish automated integration parameters, run sequences and automated sample analysis, and generate data reports)

Proficiency with Excel spreadsheets for data entry and processing, basic statistical analysis and data trending

Excellent written and verbal communication and documentation skills

Experience with analytical development for biomolecules a definite plus

Company

Selecta Biosciences

Job Code

State or Province

Massachusetts

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