Sr. Development Associate, Process Development & Manufacturing

Job Description

Geron is seeking a Sr. Development Associate to work in our Process Development & Manufacturing department. The primary responsibility will be to perform process optimization experiments for Geronís Telomerase Inhibitor Program (imetelstat sodium and other Oligos) and the peptide-paclitaxel conjugate GRN1005 using solid-phase and/or solution-phase reaction chemistry.


Operation of the Akta Oligopilot 100 DNA synthesizer and bench-scale solution-phase reactions followed by downstream process experiments such as prep scale chromatography, Ultra Filtration and Lyophilization or drying

Test and analyze R & D samples, API and drug product samples from contract manufacturers (as needed) by LC-MS, HPLCs, UV spectrophotometry

Perform Routine laboratory work such as synthesis of target compounds, standards, analysis of samples, API and drug product according to company needs. May need to use a statistical software such as the Design Expert

Record and maintain lab notebooks with detail and clarity

Maintain a clean, organized and safe working area in the lab

Record and maintain Research samples, standards, samples from contract manufacturers, Laboratory Freezers and Refrigerators

Write protocols and reports as necessary to document the results


BS/MS in Chemistry with a minimum of 2-5 years experience in synthesis of small molecules, peptides and/or oligonucleotides/nucleosides

Experience in synthetic organic chemistry especially in heterocycles and coupling reactions

Experience in NMR, HPLC, LCMS, UV and interpretation and presentation of the results to the team

Must be able to work independently and as a team

Proficiency in Word, Excel, PowerPoint, ISIS draw or ChemDraw

Outstanding written and verbal skills as well as problem solving skills

Must be able to prioritize and handle variety of tasks simultaneously

Familiarity with GMP practices and knowledge of CFR, ICH guidelines

Demonstrated team player with experience contributing to multi-disciplinary project teams and ability to work with minimal supervision

Strong initiative and ability to work in a fast-paced, dynamic environment



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